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Demonstration of the high‐affinity IgE receptor (Fc ɛ RI) on Langerhans' cells of diseased nasal mucosa
Author(s) -
Haas N.,
Hamann K.,
Grabbe J.,
Niehus J.,
Kunkel G.,
Kolde G.,
Czarnetzki B. M.
Publication year - 1997
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1997.tb01025.x
Subject(s) - immunoglobulin e , mucous membrane of nose , langerhans cell , receptor , antibody , immunology , immunoelectron microscopy , immunohistochemistry , biology , fc receptor , allergy , pathology , chemistry , antigen , microbiology and biotechnology , medicine , biochemistry
Haas N, Hamann K, Grabbe J, Niehus J, Kunkel G, Kolde G, Czarnetzki M. Demonstration of the high‐affinity IgE receptor (FcɛRI) on Langerhans' cells of diseased nasal mucosa. Langerhans' cells in the skin have recently been shown to bind IgE molecules via the high‐affinity IgE receptor (FcɛRI). Using two highly specific antibodies against the antibody‐binding α‐chain of this receptor, 29C6 and 6F7, we demonstrate by immunohistochemistry and immunoelectron microscopy that Langerhans' cells of diseased nasal mucosa can express the FcɛRI. Tissue sections from hyperplastic nasal conchae and nasal polyps of atopic and nonatopic patients have shown no basic differences in epithelial FcɛRII‐bearing cells. Only a few cells expressed the low‐affinity IgE receptor (FcɛRII) (Tül antibody) in some sections. These findings suggest that Langerhans' cells play an important role in the induction of transepithelial IgE‐mediated allergy and in the mediation of inflammation of the nasal mucosa via their FcɛRI.