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Occupational IgE‐mediated rhinitis caused by ninhydrin
Author(s) -
Hytönen M.,
Martimo K. P.,
Estlander T.,
Tupasela O.
Publication year - 1996
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1996.tb04567.x
Subject(s) - ninhydrin , provocation test , immunoglobulin e , reagent , chemistry , medicine , allergy , immunology , chromatography , antibody , biochemistry , organic chemistry , amino acid , pathology , alternative medicine
Ninhydrin is a laboratory chemical used as a reagent in the detection of free amino and carboxyl groups in proteins and peptides. We present the case of a laboratory technician who developed symptoms of rhinitis when handling papers immersed in a solution containing ninhydrin. Prick tests for ninhydrin and ninhydrin RAST were positive. The inhalation provocation test in an exposure chamber gave an immediate nasal response. A positive prick test to ninhydrin, an elevated level of specific IgE antibodies to ninhydrin, and the RAST inhibition test confirmed an IgE‐mediated type I allergic reaction. We are not aware of any other report of ninhydrin as a cause of IgE‐mediated allergy.