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Cutaneous‐mucosal allergic contact reaction due to topical corticosteroids
Author(s) -
Garijo M. A. Gonzalo,
González P. Bobadilla
Publication year - 1995
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1995.tb05058.x
Subject(s) - budesonide , triamcinolone acetonide , corticosteroid , dermatology , fluocinolone acetonide , medicine , hydrocortisone , fluticasone propionate , prednisolone , hypersensitivity reaction , surgery , immunology
We report the case of a 41‐year‐old nonatopic woman with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dematitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler. Patch tests with a series of 25 corticosteroids, some of them at different concentrations and in different vehicles, were positive to tixocortol pivalate, hydrocortisone, budesonide, prednisolone, hydrocortisone butyrate propionate, triamcinolone acetonide, and fluocinolone acetonide. For some of them, a 1 % solution in ethanol gave a positive reaction when a 20% mixture in petrolatum did not. Like other authors, we suggest that some multiple positives may represent sensitization to several steroids independently, true cross‐reactions, or both, and that ethanol is a better vehicle than petrolatum.