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Microenvironmental influences on inflammatory cell differentiation
Author(s) -
Denburg J. A.
Publication year - 1995
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1995.tb04272.x
Subject(s) - inflammation , haematopoiesis , immunology , microbiology and biotechnology , progenitor cell , cellular differentiation , bone marrow , cell , allergic inflammation , biology , epithelium , stem cell , chemistry , pathology , medicine , biochemistry , genetics , gene
Airways inflammation involves accumulation of inflammatory cells such as eosinophils, basophils and mast cells, which are derived from progenitors in marrow and blood. The inflamed tissue of the airways, through its structural (epithelium, stroma) and inflammatory cell components, produces an array of cytokines which can influence the differentiation of inflammatory cell progenitors. It is particular mechanism that we have investigated, showing that molecules such as GM‐CSF, G‐CSF, IL‐6, IL‐8 and SCF can be produced by airways epithelial cells and fibroblasts in quantities sufficient to induce hemopoietic events, either systemically or locally. Corticosteriods may act therapeutically, at least in part, to block inflammatory cell differentiation, and thus recruitment, into the allergic inflammatory process in the airways.