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Primary systemic allergy to human insulin: recurrence of generalized urticaria after successful desensitization
Author(s) -
Chng H. H.,
Leong K. P.,
Loh K.C.
Publication year - 1995
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1995.tb02512.x
Subject(s) - desensitization (medicine) , medicine , urticaria pigmentosa , insulin , allergy , regimen , drug allergy , local reaction , anesthesia , immunology , receptor
Primary systemic allergy to human insulin is rare. We report a case of recurrent immediate local reactions followed eventually by generalized urticaria to recombinant human insulin (Humulin) in an insulin‐dependent diabetic. Skin test to Humulin R was positive, and the patient was successfully desensitized using a modified rapid desensitization protocol. Two weeks later, he had another episode of generalized urticaria after Humulin R injection. His treatment was resumed at a lower dose, and within a week he was able to tolerate his usual regimen of insulin. To our knowledge, this is the first report of a recurrence of systemic reaction after successful desensitization.