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Acute autoimmune response in a case of 3yromellitic acid dianhydride‐induced hemorrhagic alveolitis
Author(s) -
Czuppon A. B.,
Kaplan V.,
Speich R.,
Baur X.
Publication year - 1994
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1994.tb02278.x
Subject(s) - trimellitic anhydride , human serum albumin , phthalic anhydride , chemistry , antigen , pyromellitic dianhydride , antibody , extrinsic allergic alveolitis , autoantibody , immunology , medicine , biochemistry , polymer chemistry , organic chemistry , lung , polyimide , layer (electronics) , catalysis
A 17‐year‐old man was occupationally exposed to pyromellitic acid dianhydride dust during the production of epoxy resin in a chemical factory. He was clinically diagnosed as having acute hemorrhagic alveolitis associated with anemia. The serologic analysis revealed a high concentration of IgG antibodies against pyromellitic acid dianhydride‐treated human serum albumin (PMDA‐HSA). Immunoblotting with PMDA‐treated human serum as antigen and the patient's serum as the first antibody showed that additional PMDA‐modified serum proteins other than HSA were recognized by the patient's IgG antibodies in the higher mol. mass range (>67 kDa). No specific IgG could be detected against other anhydride conjugates (maleic acid, MA; phthalic acid, PA) with the exception of a reaction with the trimellitic acid anhydride‐conjugated HSA (TMA‐HSA). No specific IgE antibodies could be detected against any of the above mentioned antigens, but immunoblotting of the patient's serum indicated IgG 4‐type autoantibodies against in vitro PMDA‐treated Ig molecules of normal serum proteins.