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Circulating levels of IgG1 and IgG4 Anti‐IgE antibodies and asthma severity
Author(s) -
Shakib F.,
Sihoe J.,
Smith S. J.,
Wilding P.,
Clark M. M.,
Knox A.
Publication year - 1994
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1994.tb00825.x
Subject(s) - immunoglobulin e , medicine , immunology , asthma , antibody , basophil , histamine , autoantibody , immunopathology , allergy
In this paper, we have determined the levels of IgG1 and IgG4 anti‐IgE in the sera of 66 asthma patients suffering from mild ( n = 24), moderate ( n = 23), or severe ( n = 19) symptoms, and 20 nonatopic, healthy subjects. The study has revealed that although asthma patients have significantly elevated levels of IgG1 and IgG4 anti‐IgE antibodies, the concentration of these autoantibodies is not related to the severity of asthma. This conclusion may be related to the known heterogeneity of autoanti‐IgE antibodies in terms of their ability to trigger basophil histamine release.