Premium
Markers of eosinophilic inflammation in allergic diseases
Author(s) -
Bonini S.,
Tomassini M.,
Adriani E.,
Magrini L.,
Rumi C.,
Bussa S.,
Ronchetti F.,
Bonini S.
Publication year - 1993
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1993.tb04716.x
Subject(s) - eosinophil , immunology , eosinophil cationic protein , allergic inflammation , asthma , medicine , allergy , histamine , eosinophilic , inflammation , flow cytometry , pathology
The paper reviews personal studies aimed at identifying clinical markers of eosinophil inflammation in allergic diseases. Preliminary data on the use of flow cytometry as a method to detect eosinophil activation through phenotypic activation markers are reported. The concept of eosinophil releasability is introduced on the basis of in vim eosinophil activation and mediator release by different stimuli. Data showing an increase of serum levels of ECP mainly in subjects with sensitivity to perennial allergens and related to histamine bronchial reactivity are discussed in view of their practical impact in diagnosing and monitoring of allergic diseases and asthma.