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Cross‐reactivity between quinolones
Author(s) -
Dávila I.,
Diez M. L.,
Quirce S.,
Fraj J.,
Hoz B.,
Lazaro M.
Publication year - 1993
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1993.tb02413.x
Subject(s) - quinolone , provocation test , medicine , histamine , reactivity (psychology) , dermatology , pharmacology , antibiotics , chemistry , pathology , biochemistry , alternative medicine
Cross‐reactivity between quinolones in uncertain. Recently, we studied three patients who had developed suspected allergic reaction to a quinolone. For all of them we performed skin test, histamine release test, RAST, and oral provocation with the suspected quinolone and also with another quinolone of the opposite generation. Five atopic and five nonatopic subjects were used as controls. Neither skin test, histamine release test, nor RAST was useful in the diagnosis. By mean of oral controlled provocation, the reactions were reproduced, and all the patients also reacted to another quinolone. We conclude that cross‐reactivity between quinolone seems to be very important, and avoidance of any quinolone should be recommended to any patients who has suffered an allergic reaction to one of these drugs.