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Anaphylactic reaction to ranitidine
Author(s) -
Lázaro M.,
Compaired J. A.,
Hoz B.,
Igea J. M.,
Marcos C.,
Dávila I.,
Losada E.
Publication year - 1993
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1993.tb02412.x
Subject(s) - ranitidine , medicine , histamine , anaphylactic reaction , hypersensitivity reaction , antagonist , histamine h2 receptor , anaphylactic reactions , pharmacology , ranitidine hydrochloride , allergy , dermatology , anaphylaxis , receptor , immunology
Ranitidine is a well‐tolerated H 2 ‐receptor antagonist with a furan ring a nucleus. Anaphylactic reactions are seldom reported despite the wide use the drug. We report a patient who presented an anaphylactic reaction with ranitidine (Zantac). The positive skin prick test and oral challenge suggest type I hypersensitivity. Specific IgE determination by RAST technique and histamine release test with ranitidine were negative. The patient did not react to other H 2 ‐receptor antagonists or to another furan‐derivative (nitrofurantoin).