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Elevated levels of soluble ICAM‐1 in sera from patients with bronchial asthma
Author(s) -
Hashimoto S.,
Imai K.,
Kobayashi T.,
Amemiya E.,
Takahashi Y.,
Tomita Y.,
Iwatal T.,
Suguro H.,
Yamaguchi M,
Yachi A.,
Horie T.
Publication year - 1993
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1993.tb02408.x
Subject(s) - asthma , icam 1 , medicine , immunology , downregulation and upregulation , intercellular adhesion molecule 1 , inflammation , immunoglobulin e , immunopathology , adhesion , respiratory disease , cell adhesion molecule , antibody , lung , biology , chemistry , biochemistry , gene , organic chemistry
We measured the levels of soluble intercellular adhesion molecule‐1 (sICAM‐1) in sera from patients with bronchial asthma. sICAM‐1 levels in sera from atopic asthmatic patients in stable conditions were higher than in normal control subjects. Furthermore, the sICAM‐1 levels in sera obtained during bronchial asthma attacks were higher than those in sera obtained in stable conditions. These results suggest that higher levels of sICAM‐1 in sera reflect the upregulation of ICAM‐1 expression in allergic inflammation.