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The effect of oral drugs on the cytologic picture of nasal mucosa in hay fever
Author(s) -
TarchalskaKryńska B.,
Zawisza E.
Publication year - 1993
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1993.tb02398.x
Subject(s) - medicine , mucous membrane of nose , hay fever , decongestant , antihistamine , phenylephrine , eosinophilia , nose , nasal decongestant , pseudoephedrine , mucous membrane , anesthesia , allergy , gastroenterology , pathology , immunology , surgery , ephedrine , blood pressure
The aim of the present study was to assess the influence of H 1 ‐antihistamine and sympathomimetic drugs given orally on eytologic smears of the nasal mucosa. Thirty‐five patients with hay fever evaluated cytologic smears of the nasal mucosa before and after a 2‐week treatment. Fourteen patients received chlorpheniramine with phenylephrine, 10 patients dexchlorpheniramine, and 11 patients pseudoephedrine. The investigated drugs significantly changed nasal cytograms. The number of eosinophils increased after chlorpheniramine with phenylephrine and after pseudoephedrine but decreased after dexchlorpheniramine. Thus, the sympathetic nervous system stimulation seems to produce local eosinophilia on the nasal mucosa. In view of such a significant correlation between hay fever symptoms and the number of eosinophils in the cytograms, it can be concluded that the combination of antihistamine and sympathomimetic drugs may adversely affect the course of the disease. Although, at the initial stage of the treatment, sympathomimetics reduce swelling and improve the patency of the nose through decongestion of the blood vessels, their negative effect can influence the immunologic mechanisms.