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Effects of H 1 ‐receptor antagonists on nasal obstruction in atopic patients
Author(s) -
Horak F.,
Toth J.,
Jäger S.,
Berger U.
Publication year - 1993
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1993.tb00720.x
Subject(s) - rhinomanometry , medicine , astemizole , histamine h1 receptor , itching , placebo , antihistamine , anesthesia , allergy , provocation test , nasal administration , airway resistance , allergen , dermatology , nose , antagonist , surgery , airway , receptor , pharmacology , immunology , pathology , alternative medicine
The aim of this study is to investigate whether H 1 ‐receptor antagonists, besides their effect on nasal itching and sneezing, also have a measurable effect on nasal obstruction caused by allergen challenge. The antihistamine used was astemizole (10 mg) versus placebo, in a double‐blind, cross‐over, randomized study of two groups. Between the two sessions there was a wash‐out period of at least 4 weeks. Seven patients of both sexes, with proven allergy to grass pollen, underwent a specific long‐term provocation with grass pollen in the Vienna challenge chamber. Using a physiological method of challenge and a sensitive method for evaluating nasal function, we were able to prove H 1 ‐receptor antagonist influence on nasal airway obstruction. The main parameters obtained arc nasal flow and nasal resistance at 75, 150 and 300 Pa, evaluated by active anterior rhinomanometry. We also investigated subjective symptom scores (0–3) of nasal, eye. and lung symptoms. It can be shown that the nasal flow under astemizole treatment is statistically significantly higher than the nasal flow under placebo treatment ( P = 0.034). This is in accordance with the findings in subjective nasal itching and sneezing.