Premium
Diurnal variation of urinary histamine and 1‐methylhistamine excretion in healthy children
Author(s) -
Schulze S.,
Niggemann B.,
Savaser A. N.,
Wahn U.
Publication year - 1992
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1992.tb02389.x
Subject(s) - histamine , circadian rhythm , urinary system , excretion , urine , diurnal temperature variation , endocrinology , medicine , radioimmunoassay , geology , atmospheric sciences
In order to establish a noninvasive method of monitoring immediate hypersensitivity reactions in children, we studied the diurnal variation of urinary histamine and 1‐methylhistamine excretion and the influence of food intake in a group of 14 healthy nonatopic children (aged 2–16 years). Histamine and 1‐methylhistamine in spontaneous urine samples were determined by radioimmunoassay. Mean variation of 2–h intervals was much higher for urinary histamine than for 1‐methylhistarnine (45% of base‐line level versus 24%). There was no circadian rhythm or influence of food intake. The short half‐life of histamine released into blood circulation may be the main reason for the higher variation of histamine excretion. In children, urinary 1‐methylhistamine is less influenced by diurnal variation and is therefore more suited to monitor immediate hypersensitivity reactions than urinary histamine itself.