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Effect of astemizole on antigen‐mediated histamine release from the blood of patients with allergic rhinitis
Author(s) -
Faraj B. A.,
Jackson R. T.
Publication year - 1992
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1992.tb02386.x
Subject(s) - astemizole , histamine , medicine , histamine h1 receptor , pharmacology , allergy , potency , allergen , terfenadine , antagonist , immunology , in vitro , receptor , chemistry , biochemistry
The main objective of this study was to test the effectiveness of astemizole in vitro in blocking the release of histamine from blood of patients with allergic rhinitis. The results of this investigation indicated that astemizole inhibited allergen‐mediated histamine release from blood basophils of patients with this allergic disorder. The inhibition by astemizole (33–156 μmol) was immediate, requiring no pre‐incubation of the cells, and was dose‐dependent, with maximal inhibition of about 91%. The relatively high potency of astemizole in inhibiting the immunologic release of histamine may provide an additional measure in the treatment of allergic rhinitis with this H i‐receptor antagonist.