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Basophil histamine release in patients with birch pollen hypersensitivity with and without allergic symptoms to fruits
Author(s) -
KleineTebbe J.,
Galleani M.,
Jeep S.,
Pilz B.,
Baisch A.,
Kunkel G.
Publication year - 1992
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1992.tb02384.x
Subject(s) - histamine , basophil , allergy , immunoglobulin e , immunology , sensitization , pollen , allergen , basophil activation , medicine , oral allergy syndrome , biology , botany , antibody
Histamine release (HR) studies were performed in 40 birch pollen‐allergic patients (positive case history, positive SPT, positive birch pollen‐specific serum IgE: RAST ≤ 3) with ( n = 20, A) and without ( n = 20, B) fruit hypersensitivity, and 10 nonatopic volunteers (C). Several fruit allergens were used and characterized by protein determination and immunoblot techniques. Dose‐dependent HR (apple peel = apple pulp> peach = cherry) was demonstrated in both allergic groups, but to a higher extent in patients with fruit allergy ( P < 0.01). Increased basophil sensitivity to birch pollen was found in the group with fruit allergy ( P < 0.001). Strong correlations between the mediator response induced by several fruits indicate common allergens within the extracts. We conclude that fruit‐related symptoms require not only high specific serum IgE, but a strong cellular sensitization to birch pollen allergens together with an increased cellular reactivity to fruit allergens.