Premium
Delayed hypersensitivity to 6‐methyl‐prednisolone in Henoch Schoenlein syndrome
Author(s) -
Astone A.,
Romano A.,
Pietrantonio F.,
Garcovich A.,
Venuti A.,
Barone C.
Publication year - 1992
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1992.tb02085.x
Subject(s) - prednisolone , medicine , dermatology , rash , patch test , purpura (gastropod) , allergy , hypersensitivity reaction , skin biopsy , biopsy , gastroenterology , immunology , ecology , biology
We report a case of allergic reaction to oral 6‐methyl‐prednisolone in a patient with Henoch Schoenlein syndrome. When this syndrome was first diagnosed the patient was started on 6‐methyl‐prednisolone orally and after 4 days he developed a pruriginous generalized maculo‐papular eruption. The rash disappeared 1 week after withdrawal of 6‐methyl‐prednisolone. The skin tests performed 1 month after with main food allergens were negative. Patch test with 0.10 ml of solution containing 6‐methyl‐prednisolone 40 mg/ml was positive after 48 and 72 h. The cutaneous biopsy on the patch tested skin revealed a perivaseular infiltrate of lymphocytes, histiocytes and eosinophils.