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Cord blood IgE. II. Prediction of atopic disease
Author(s) -
Hansen L. G.,
Høst A.,
Halken S.,
Holmskov A.,
Husby S.,
Lassen L. B.,
Storm K.,
Østerballe O.
Publication year - 1992
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1992.tb02079.x
Subject(s) - atopy , cord blood , medicine , immunoglobulin e , immunology , family history , allergy , disease , pediatrics , antibody
Screening of total IgE in 2814 cord blood samples was analysed by Phadebas IgE PRIST in 2 1‐year birth cohorts (1983‐1984 and 1985–1986) in Denmark ( n = 1189 + 1625). For follow‐up we chose all infants with cord blood IgE ≥ 0.5 kU/1 and a randomly chosen group of the same size with cord blood IgE < 0.5 kU/1. A total of 762 infants were clinically evaluated at 18 months of age. A diagnosis of definite atopy, probable atopy or no atopy, including both IgE and non‐IgE mediated disease was established. Applying different cord blood IgE cut‐off values (0.3, 0.5, 0.8, 1.1) we did not find an excess of atopic infants among those with elevated cord blood IgE irrespective of the chosen cut‐off value. Atopic predisposition or family history of atopic disease was defined as at least one parent or older siblitig with atopic disease. Significantly more infants with a family history developed atopy at 18 months. In the 2 series the positive predictive values of cord blood IgE≥0.5 were 43% and 46% and the sensitivities were 17% and 15%. The predictive values of having a family history were 48% and 44% and the sensitivities were 55% and 58%. Clinical aspectsCord blood IgE analysed by Phadebas IgE PRIST was a poor predictor of infants developing atopic disease before the age of 18 months.