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Severe hypersensitivity reaction to injectable Gallium 67 in a worker exposed to silica
Author(s) -
Commandeur C.,
Richard M.,
Renzi P. M.
Publication year - 1992
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1992.tb02066.x
Subject(s) - medicine , hypersensitivity reaction , silicosis , gallium , pneumoconiosis , anaphylaxis , scintigraphy , delayed hypersensitivity , gallium 67 scan , allergic reaction , isotopes of gallium , skin reaction , allergy , dermatology , pathology , radiology , immunology , immune system , chemistry , organic chemistry
Gallium 67 scintigraphy is employed in the evaluation of workers with possible pneumoconiosis. To our knowledge, however, a severe hypersensitivity reaction following the intravenous injection of Gallium 67 has not been described. We report the ease of a worker chronically exposed to silica who developed an allergic cutaneous and severe articular reaction following the injection of Gallium 67 while being investigated for possible silicosis. Hilar adenopathy was noted on the chest roentgenogram and, retrospectively, circulating immune complexes were found in the patient's serum. The presence of a positive prick skin test to benzyl alcohol suggests that this preservative caused the hypersensitivity reaction.