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Nasal memory T lymphocytes capable of producing IL‐4 in the allergic reaction
Author(s) -
Hellquist H. B.,
Karlsson M. G.
Publication year - 1992
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1992.tb02065.x
Subject(s) - mucous membrane of nose , immunology , immunoglobulin e , allergy , interleukin 4 , allergic inflammation , t lymphocyte , t cell , mast cell , nasal allergy , medicine , cytokine , biology , immune system , antibody
This paper reports the presence of memory T cells in the nasal mucosa of allergic patients. The demonstration of CD4 +/CD29 + (CD4 +/CD45RO +) T lymphocytes, which are capable of interleukin‐4 production, can indicate a complementary cell‐mediated regulatory mechanism for mast cell proliferation and IgE synthesis in human nasal allergy. No substantial IgE production can be obtained in the absence of IL‐4. Therefore, the existence of IL‐4 producing cells on site in the nasal mucosa of allergic subjects probably implies a complementary interaction between cytokines and different immunocompetent nasal cells in the regulation of B cells and IgE synthesis.