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Circulatory basophilia in guinea pigs with delayed‐type hypersensitivity
Author(s) -
Sompolinsky D.,
Katzenstein T.,
Lundberg L.
Publication year - 1992
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1992.tb02058.x
Subject(s) - basophilia , ovalbumin , circulatory system , immunology , adjuvant , freund's adjuvant , medicine , guinea pig , spleen , immune system , endocrinology
Circulatory basophilia could be induced in inbred guinea pigs systematically immunized with ovalbumin and consequently provoked repeatedly with dissolved ovalbumin applied onto the mucosa of the nares or the outer eye. The degree of the increase in circulatory basophil granulocytes depended on the adjuvant used and was significantly more pronounced after immunization with Freund's complete adjuvant than with alhydrogel (A1(OH)3). The degree of basophilia was also dependent on the animal strain, but different in two strains selected for high‐asthma trait.