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Measurement of PC 20 histamine with the use of two different nebulizers and measurement of FEV 1 and PEF
Author(s) -
Iversen M.,
Harving H.,
Pedersen B.
Publication year - 1991
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1991.tb00573.x
Subject(s) - histamine , nebulizer , medicine , reproducibility , anesthesia , chemistry , pharmacology , chromatography
Histamine challenge was performed in 19 patients using two nebulizers (PARI and Wright) and FEV 1 and PEF were measured to determine PCOT histamine. FEV 1 and PEF gave identical PC20 histamine values. The PARI nebulizer gave PC 20 histamine values that were 2.5 doubling concentrations lower than the Wright nebulizer. The reproducibility of histamine challenge with the PARI nebulizer1 was studied in 15 patients and the results suggested that the challenge was reproducible within one doubling concentration of histamine.