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HIV antigen‐induced release of histamine from basophils from HIV infected patients
Author(s) -
Pedersen M.,
Nielsen C. M.,
Permin H.
Publication year - 1991
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1991.tb00572.x
Subject(s) - histamine , basophil , immunology , asymptomatic , medicine , antigen , sensitization , immunopathology , disease , allergy , immunoglobulin e , immunodeficiency , antibody , immune system
Basophil leukocytes from 39 HIV‐infected patients with various degrees of immunodeficiency and disease progression were stimulated with an HIV antigen preparation. Cells from 19 of 22 patients with AIDS and all of six patients with milder degrees of HXV‐related disease showed significant histamine release. In contrast, cells from 11 asymptomatic HIV‐infected patients and 11 healthy control persons released no histamine. The histamine release induced by HIV antigen was found to be inversely correlated to the number of CD4 positive T lymphocytes. These results indicate that the histamine release was related to both the clinical stage of disease and the degree of immunodeficiency. Passive sensitization experiments showed that IgE, but not IgG, was reponsible for the induction of histamine release, indicating the reaction to be type 1 allergic. The histamine release caused by HIV might be involved in the development of disease because of the immunomodulating properties of this mediator.