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Bricanyl® Turbuhaler® and Ventolin® Rotahaler® in exercise‐induced asthma in children
Author(s) -
Lopes Dos Santos J. M.,
Costa H.,
Ståhl E.,
Wirén J. E.
Publication year - 1991
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1991.tb00571.x
Subject(s) - salbutamol , medicine , asthma , placebo , terbutaline , bronchodilator , anesthesia , inhalation , exercise induced asthma , inhaler , crossover study , adverse effect , physical therapy , alternative medicine , pathology
Bricanyl® Turbuhaler® (0.5 mg terbutaline sulphate) and Ventolin® Rotahaler® (0.4 mg salbutamol) were compared in a randomized double‐blind placebo controlled study on exercise‐induced asthma in 19 children (14 boys) aged 7‐14 years. The study was carried out on 3 separate days. Asthmatic attacks were provoked by free range running. Peak expiratory flow (PEF) was measured before and after exercise. If PEF decreased by > 20 %, one inhalation from each of the inhalers was given under supervision of the investigator. Only one of the inhalers (none on the placebo day) delivered active drug. PEF was measured again 5 and 10 min after treatment. Already 5 min after treatment PEF had returned to baseline after active treatment. There was no statistically significant difference between the two active treatments. After placebo treatment, PEF did not return to baseline even at the 10 min post‐exercise measurement. Ten children needed extra medication after the last PEF measurement on the placebo day, whereas no child needed extra medication after any of the active treatments. No adverse events were reported in this study. In conclusion, Bricanyl Turbuhaler (0.5 mg) and Ventolin Rotahaler (0.4 mg) were equally efficacious in the treatment of exercise‐induced asthma in children.