Premium
Virus, bacteria and lipopolysaccharide increase basophil cell response to histamine releasing stimulators and calcium
Author(s) -
Clementsen P.,
Kristensen K. S.,
Norn S.
Publication year - 1991
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1991.tb00557.x
Subject(s) - histamine , lipopolysaccharide , basophil , calcium , extracellular , immunology , allergic response , chemistry , immunoglobulin e , microbiology and biotechnology , biology , pharmacology , biochemistry , antibody , organic chemistry
Histamine release from human basophil leukocytes from allergic patients or controls was induced by specific antigens, anti‐IgE or calcium ionophore A23187, Influenza A virus, S. aureus and lipopolysaccharide from S. typhimurium increased the maximum release of histamine and caused a shift lo the left of the dose‐response curves showing increased cell sensitivity and lowering of the threshold to these stimuli. The mechanism of action was elucidated by examining the mediator release as a function of increasing extracellular concentration of calcium, in these experiments the dose‐response curves were changed by the microorganisms and lipopolysaccharide as before. This indicates that the microorganisms and lipopolysaccharide change the basophil cell response to IgE‐dependent and non‐immunological stimuli by causing a change in the subcellular handling of calcium.