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Capsaicin pretreatment does not inhibit allergen‐induced airway microvascular leakage in guinea pig
Author(s) -
Lötvall J. O.,
Hui K. P.,
Löfdahl C. G.,
Barnes P. J.,
Chung K. F.
Publication year - 1991
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1991.tb00552.x
Subject(s) - capsaicin , guinea pig , ovalbumin , allergen , medicine , airway , vascular permeability , pharmacology , immunology , allergy , anesthesia , receptor , immune system
We have studied the effects of tachykinin‐depletion on airway microvascular leakage induced by allergen challenge in ovalbumin‐sensitised guinea pigs, Tachykinin‐depletion was obtained by capsacin pretreatment 1 week before inhaled allergen challenge. Capsaicin pretreatment did not change airway microvascular permeability induced by allergen challenge. Capsaicin pretreatment did not change airway microvascular permeability induced by allergen challenge. Thus, sensory neuropeptides may not be important in allergen induced acute airway microvascular leakage in guinea pig in vivo.