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Cutaneous and basophilic sensitivity to substance P and gastrin in non‐atopic versus atopic subjects
Author(s) -
Louis R. E.,
Radermecker M. E.
Publication year - 1991
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1991.tb00539.x
Subject(s) - histamine , substance p , basophilic , medicine , asymptomatic , gastrin , immunoglobulin e , asthma , intradermal injection , immunology , endocrinology , neuropeptide , pathology , receptor , antibody , secretion
We compared the Cutaneous reaction to intradermal injection of substance P, gastrin and histamine in asymptomatic atopic subjects with a history of hay fever and/or asthma versus non‐atopk healthy volunteers. We also studied in these two groups the basophilic histamine release induced by substance P and gastrin with that obtained with anti‐human IgE and Con A. Intradermal injection of substance P (3–300 pM) and gastrin (3–30 pM) caused a wheal and flare reaction which was comparable in both groups of subjects. Substance P 10 −4 M caused a mean basophilic histamine release of about 15% in atopic and non‐atopic Subjects. Gastrin was not effective in this model. Anti‐IgE and Con A‐induced histamine release was significantly higher in atopic than in non‐atopic volunteers.