Premium
A double‐blind study of hyposensitization with an alginate‐ conjugated extract of Dermatophagoides pteronyssinus (Conjuvac®) in patients with perennial rhinitis
Author(s) -
Pastorello E. A.,
Ortolani C.,
Incorvaia C.,
Farioli L.,
Italia M.,
Pravettoni V.,
Harris R. J.,
Watson H. K.,
Corrado O. J.,
Davies R. J.,
Zanussi C.
Publication year - 1990
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1990.tb00526.x
Subject(s) - immunoglobulin e , medicine , immunology , subclass , placebo , antibody , allergen , allergy , pyroglyphidae , desensitization (medicine) , mite , immunotherapy , immunopathology , gastroenterology , house dust mite , immune system , biology , pathology , receptor , alternative medicine , botany
In a 2‐year double‐blind placebo controlled study an immunological evaluation was carried out on 33 patients (15 males, 18 females, mean age 29.2 years) with mite‐induced perennial rhinitis who were submitted to specific immunotherapy (IT) with an alginate‐conjugated extract of D. pteronyssinus. The behaviour of IgE, IgG, IgG 1 , and IgG 4 , antibodies specific to D. pteronyssinus and its major allergen Der p 1 , was characterized by assessment of their changes m serum, and changes in IgG in nasal secretions during the treatment. The placebo‐treated patients did not show any significant variation in the levels of specific antibodies, while in the actively treated patients we found; a statistically significant decrease ( P < 0.005) of specific IgE, a statistically significant increase of specific IgG ( P < 0.005), IgG 1 , ( P < 0.005) and IgG 4 ( P < 0.005) in serum and a statistically significant increase ( P < 0.001) of specific IgG in nasal secretions. The IgG response showed an early relative predominance of the IgG 1 subclass and a late absolute predominance of IgG 4 subclass, that confirmed the model of IgG 4 restriction in prolonged allergen stimulation. No correlation was found between immunological and clinical data.