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Effects of one‐year hyposensitization in allergic rhinitis
Author(s) -
Pécoud A.,
Nicod L.,
Badan M.,
Agrell B.,
Dreborg S.,
Kolly M.
Publication year - 1990
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1990.tb00516.x
Subject(s) - medicine , immunology , provocation test , immunoglobulin e , allergy , skin reaction , house dust mite , allergen , gastroenterology , antibody , pathology , alternative medicine
In an open study, 21 patients suffering from chronic non‐seasonal rhinitis and allergic to house mites (HDM) have been treated for 1 year with either a new extract (Pharmalgen; n = 10) or an allergoid, pyridine denatured, extract (Alavac; n = 11), both precipitated with AlOH 3 , (depot). The following investigations were performed before and after therapy: clinical scoring (for 4 weeks), quantified skin prick tests (SPT) and nasal provocation tests (NPT) with HDM, and determination in serum of HDM‐specific IgE and IgG. Both groups were compared with six patients who remained untreated and underwent the same investigations. Hyposensitization with either extract induced an improvement in clinical scores ( P < 0.05), a decrease in SPT reactivity (Pharmalgen: P < 0.001; Alavac: P < 0.01), a marked increase in the nasal tolerance to HDM ( P < 0.001) and in HDM‐specific IgG ( P < 0.001). In the group of untreated patients, all these parameters remained unchanged. Compared with the Alavac extract, the Pharmalgen extract was more active in decreasing SPT reactions ( P < 0.05) and inducing a HDM‐specific IgG rise ( P < 0.05). Although both extracts induced some untoward allergic reactions, no adrenaline was used at any time during the study. These data suggest that hyposensitization with depot extracts of HDM can be considered a safe and active adjunct to the treatment of allergic rhinitis.