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Effect of ketanserin, a new blocking agent of the 5‐HT 2 receptor, on airway responsiveness in asthma
Author(s) -
Cazzola M.,
Assogna G.,
Lucchetti G.,
Cicchitto G.,
D'Amato G.
Publication year - 1990
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1990.tb00473.x
Subject(s) - ketanserin , medicine , asthma , methacholine , pharmacology , serotonin , receptor antagonist , drug , anesthesia , airway obstruction , antagonist , adverse effect , 5 ht receptor , receptor , respiratory disease , airway , lung
Most of the antihypertensive drugs have a liability for adverse effects in asthma. Since there are few available data on the effect of ketanserin, a new antihypertensive drug which is a type‐2 serotonin receptor antagonist, on human respiratory function, we have tested whether this drug can modify bronchial hyperresponsiveness to methacholine in asthmatic patients. The protective effect of intravenous ketanserin (0.14 mg/kg) was small, but significant.