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Hypomagnesemia and bronchial hyperreactivity
Author(s) -
ROLLA G.,
BUCCA C.
Publication year - 1989
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1989.tb04192.x
Subject(s) - hypomagnesemia , histamine , medicine , magnesium , contractility , asthma , bronchial obstruction , magnesium deficiency (plants) , endocrinology , gastroenterology , anesthesia , chemistry , organic chemistry
In a 37‐year‐old woman, a heavy smoker and an alcoholic, bronchial hyperreactivity to histamine (PC 20 FEV 1 0.8 mg/ml) was related to hypomagnesemia (0.55 mmol/l). After acute magnesium repletion (24 h i.v. infusion MgSO 4 6 g, serum magnesium 1.05 mmol/l), histamine PC 20 FEV 1 increased up to 9.8 mg/ml. The role of magnesium in modulating smooth muscle contractility is discussed and the importance of checking serum magnesium in patients with airway obstruction is suggested.