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Basophil histamine release and lymphocyte proliferation tests in latex contact urticaria
Author(s) -
Turjanmaa K.,
Räsänen L.,
Lehto M.,
MäkinenKiljunen S.,
Reunala T.
Publication year - 1989
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1989.tb02259.x
Subject(s) - histamine , basophil , immunology , latex allergy , allergen , lymphocyte , medicine , allergy , contact allergy , basophil activation , contact urticaria , contact dermatitis , immunoglobulin e , antibody
Basophil histamine release and lymphocyte proliferation tests were examined with latex allergen prepared from surgical gloves in 15 patients with latex contact urticaria. The basophil histamine release test (BHRT) yielded positive results in 13/14 (93%) patients, whereas commercial latex RAST was positive in only 9/15 (60%) patients. Lymphocyte proliferation test (LPT) was positive in 3/15 (20%) patients, suggesting that cell‐mediated immune reactions may also occur in latex allergy. However, patch tests to latex were negative and neither were epidermal Langerhans cells able to present latex antigen to T lymphocytes in vitro.