Premium
Influenza A virus enhances Staphylococcus aureus ‐induced basophil histamine release in normal individuals and patients with intrinsic asthma
Author(s) -
Clemensten P.,
Jensen C. B.,
Jarløv J. O.,
Hannoun C.,
Søborg M.,
Norn S.
Publication year - 1989
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1989.tb00444.x
Subject(s) - neuraminidase , histamine , neuraminidase inhibitor , staphylococcus aureus , virus , microbiology and biotechnology , immunology , respiratory tract , influenza a virus , allergy , virology , biology , medicine , respiratory system , bacteria , pharmacology , genetics , disease , covid-19 , infectious disease (medical specialty)
Influenza A virus was found to enhance Staphylococcus aureus‐ histamine release in human leukocyte suspensions, but did not per se release histamine. This potentiating effect was found to be similar in cells from normal individuals and from patients with intrinsic asthma. The enhancement of mediator release could be due to viral neuraminidase on the surface of the virus, since a similar potentiating effect was caused by a purified neuraminidase preparation obtained from Vibrio cholerae , and the effect of virus as well as of the purified neuraminidase was completely abolished by a potent neuraminidase inhibitor. The potentiating effect of virus on bacteria‐induced mediator release might be of importance for the conversion from latent to manifest asthma in upper respiratory tract infections.