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Increased peripheral α‐adrenoceptor response in allergic asthmatics
Author(s) -
Sandström T.,
Henriksson R.,
Hörnkvist R.,
Bäck O.,
Rosenhall L.
Publication year - 1988
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1988.tb02043.x
Subject(s) - medicine , asthma , peripheral , phenylephrine , allergic response , allergic asthma , blanching , methacholine , allergy , immunology , respiratory disease , immunoglobulin e , lung , chemistry , antibody , food science , blood pressure
The peripheral α‐adrenoceptor reactivity, measured as dermal blanching response to iontophoretically administered phenylephrine, was studied in 28 allergic asthmatics, 13 patients with allergic rhinoconjunctivitis and 21 healthy controls. The blanching response, which has previously been demonstrated to be mediated via α 1 ‐adrenoceptors, was found to be significantly increased in allergic asthmatics compared with controls. It is suggested that there is an increased peripheral α‐adrenoceptor reactivity in allergic asthma.