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Bambuterol: clinical effects of three doses of bambuterol once daily in asthmatic patients
Author(s) -
Clelmmensen I. H.,
Pedersen B. K.,
Ravn S.,
Laursen L. C.,
Weeke B.
Publication year - 1988
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1988.tb00929.x
Subject(s) - terbutaline , evening , medicine , crossover study , asthma , anesthesia , bronchodilator , pathology , astronomy , placebo , physics , alternative medicine
Twenty‐two asthmatics received bambuterol solution, a terbutaline pro‐drug, once every evening. The following doses were each given orally for 7 days in a double‐blind crossover study: 0.185, 0.270 and 0.400 mg/kg. Bambuterol 0.270 mg/kg was preferable regarding clinical effects and side effects. The plasma concentration of generated terbutaline showed a slow linear decrease at all doses. Tests of two methods for objective measurements of tremor in five patients did not add any new data compared with the subjective recordings.