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Immunological changes associated with a successful outcome of pollen immunotherapy
Author(s) -
Fennerty A. G.,
Jones K. P.,
Davies B. H.,
Fifield R.,
Edwards J.
Publication year - 1988
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1988.tb00911.x
Subject(s) - immunotherapy , hay fever , medicine , immunology , immunoglobulin e , monoclonal antibody , allergy , antigen , antibody , immune system
Changes in immunological measurements thought to be important in the mechanism of immunotherapy for hay fever were related lo objective measurements of treatment outcome. Antigen‐specific IgE and IgG, and T suppressor cell status, using monoclonal antibodies and a specific functional assay, were measured before and after immunotherapy. Treatment outcome was assessed using nasal and conjunctival challenge tests. Seventeen subjects received immunotherapy for 6 months. Nine showed a decrease in nasal and/or conjunctival sensitivity, compared with 2 of 13 control subjects ( P < 0.05). Subjects responding to immunotherapy had a significantly higher post treatment IgE level and a higher pre‐ and post‐treatment IgG level than non‐responders and controls. Immunotherapy had no effect on suppressor cell status.

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