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Human immune response to allergens of house dust mite, Dermatophagoides pteronyssinius
Author(s) -
SaintRemy J. M. R.,
Lebrun P. M.,
Lebecque S. J.,
Masson P. L.
Publication year - 1988
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1988.tb00427.x
Subject(s) - house dust mite , allergen , immune system , immunology , pyroglyphidae , mite , dust mites , medicine , allergy , acari , biology , zoology , ecology
Specific antibodies isolated by immunoabsorption on four main insolubilized allergens from Dermatophagoides pteronyssinus (DPT) had the following isotypic distribution: in 16 atopic patients, 52% IgG, 40% IgM, 8% IgA, 0.1% IgE and, in 12 non‐atopic individuals, 48% IgG, 46% IgM, 6% IgA, 0.03% IgE. The ratios between geometric means of antibody values in each class (atopic vs non‐atopies) were 2.4 for IgG, 2.0 for IgM, 2.8 for IgA and 66.7 for IgE. The amount of anti‐DPT antibodies in IgG subclasses (did not follow the usual distribution of total IgG subclasses, i.e., IgG1 > lgG2 > IgG3 > IgG4. In atopies the order was IgG2 > IgG1 > IgG4 > lgG3 and in non‐atopies, IgG4 > IgGl ‐ IgG2 > IgG3 although 6/12 of the latter had no detectable (< 0.5 μg/ml plasma) IgG4.