Premium
Lymphocyte proliferative responses to the purified Dermatophagoides farinae major allergen in untreated and hyposensitized atopic patients
Author(s) -
Cavaillon J.M.,
Fitting C.,
Guinnepain M.T.,
Rassemont R.,
David B.
Publication year - 1988
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1988.tb00409.x
Subject(s) - allergen , immunology , peripheral blood mononuclear cell , medicine , house dust mite , lymphocyte , atopy , peripheral blood , allergy , atopic dermatitis , immunoglobulin e , mite , antibody , in vitro , biology , biochemistry , botany
We investigated the proliferative response of lymphocytes from mite‐sensitive patients (RAST D.far > 3.5 PRU/ml) in the presence of the major allergen Der.f.I purified from Dermatophagoides farinae . Comparative studies were carried out with peripheral blood mononuclear cells from non‐atopic donors (RAST = 0), and from patients undergoing hyposensitization treatment (5 to 24 months). According to Student's t‐test, there was no significant difference in the Der.f. I‐induced proliferation of peripheral blood mononuclear cells from normal donors, untreated atopic patients and hyposensitized patients. In conclusion, it was impossible to discriminate between normal donors, atopic patients and hyposensitized patients with regard to their circulating lymphocyte responses to the purified major allergen Der.f.I.