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Basophil histamine release in insect venom allergy
Author(s) -
Engel T.,
Heinig J. H.,
Weeke E. R.,
Schwartz B.,
Ingemann L.
Publication year - 1988
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1988.tb00407.x
Subject(s) - histamine , sting , basophil activation , venom , basophil , allergy , medicine , immunoglobulin e , immunology , anaphylaxis , insect bites and stings , pharmacology , biology , antibody , ecology , engineering , aerospace engineering
The aim of the present study was to investigate venom‐related and venom‐non‐related immunological reactions in patients stung by bee or wasp. Sixteen consecutive patients (7 with local and 9 with systemic reactions) were tested with skin tests, RAST and basophil histamine release (BHR) test immediately after the insect sting and 2, 4, and 16 weeks later. No test was useful immediately after the insect sting, the “anergic period”. In agreement with earlier findings, the SPT was the only allergy test that showed statistically significant differences between patients with local and systemic reactions, although a great overlap was found. Release of histamine from basophils after incubation with anti‐IgE also showed statistically significant differences between local and systemic reactions. Further studies are needed, especially measurement of BHR after incubation with anti‐IgE before insect stings.