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In vitro diagnosis of atopic allergy in children
Author(s) -
Gustafsson D.,
Danielsson D.
Publication year - 1988
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1988.tb00402.x
Subject(s) - medicine , immunoglobulin e , radioallergosorbent test , allergy , immunology , intoxicative inhalant , respiratory allergy , allergen , antibody , biology , toxicology
A new multi RAST (Phadiatop®) was compared with conventional RAST and total IgE determination (PRIST) for the diagnosis of IgE‐mediated allergy in children. Serum specimens were tested from 100 children with a suspected IgE‐mediated allergy, restricted to the eyes and/or the respiratory tract, to inhalant allergens. Compared with a RAST panel of 12 allergens representing seven groups, the new multi RAST showed a sensitivity of 95% and a specificity of 100% with a predictive value for positive test of 100% and for negative test of 91%. Corresponding figures for total IgE elevated > 2 SD above mean determined with PRIST were 47%, 88% 84% and 56% respectively. We conclude that multi RAST might be a good adjunct to the clinical diagnosis of IgE‐mediated allergy to inhalant allergens.