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Substance P and vasoactive intestinal peptide in serotonin‐induced nasal secretions in normal subjects
Author(s) -
Tønnesen P.,
Muckadell O. B. Schaffalitzky de
Publication year - 1987
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1987.tb02373.x
Subject(s) - vasoactive intestinal peptide , methysergide , substance p , serotonin , endocrinology , atropine , medicine , radioimmunoassay , peptide hormone , chemistry , nasal administration , neuropeptide , pharmacology , receptor
The aim of this study was to examine if nasal secretions contained substance P and/or vasoactive intestinal peptide. Serotonin nasal challenge was performed in 14 normal subjects 15 min after intranasal pretreatment (double‐blind) with atropine, methysergide, chlorpheniramine or isotonic saline. Serotonin induced a dose dependent increase in secretion ( P < 0.05), and only pretreatment with atropine reduced the secretion ( P < 0.02). Substance P, measured by radioimmunoassay, was found in all of the examined secretions ( n = 100) with a median concentration of 13.7 pmol/1 (range 1.7–125.0). Serotonin challenge increased the concentration or content of substance P in a dose‐related fashion ( P < 0.01). The different pretreatments did not affect the concentration of substance P. Vasoactive intestinal peptide was found in low concentration in 37% of the secretions with a median concentration of 0 pmol/1 (range 0–50.0).