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Studies on the anti‐allergic action of N‐(3′,4′dimethoxycinnamoyl) anthranilic acid (N‐5′)
Author(s) -
Hamel R.,
FordHutchinson A. W.,
Piechuta H.
Publication year - 1987
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1987.tb02211.x
Subject(s) - anthranilic acid , action (physics) , chemistry , medicine , pharmacology , biochemistry , physics , quantum mechanics
The effects of the anti‐allergic compound N‐(3′,4′‐dimethoxycinnamoyl) anthranilic acid (N‐5′ or Tranilast) have been investigated upon antigen‐induced contractions of respiratory smooth muscle in vitro and bronchoconstriction in vivo. N‐5′ (3.1 × 10 −5 M) in vitro had no significant effect upon antigen‐induced contractions of the guinea pig trachea. However, when tested at concentrations of 9.2 and 3.1 × 10 −5 M, but not 0.9 × 10 −5 , N‐5′ significantly inhibited antigen‐induced contractions of the human parenchyma. In vivo N‐5′ (5 and 10 mg/kg p.o.) failed to inhibit antigen‐induced dyspnea in hyperreactive rats, N‐5′ (20 mg/kg p.o.) also failed to inhibit the immediate bronchoconstriction following ascaris challenge of conscious squirrel monkeys but significantly attenuated the reduction in dynamic compliance during the pulmonary late phase response observed between 4 and 10 h after antigen challenge. It is suggested that N‐5′ does not act as a “cromoglycate‐like” compound but may have novel mechanisms of action in human bronchial asthma.