Premium
Detailed IgG and IgE antibody patterns during immunotherapy with honey bee venom
Author(s) -
Uhlin T.,
Nordvall S. L.,
ÖHman S.,
Einarsson R.
Publication year - 1987
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1987.tb02203.x
Subject(s) - immunoglobulin e , immunology , medicine , antibody , immunotherapy , allergy , radioallergosorbent test , venom , biology , immune system , ecology
Fourteen patients with a known honey bee venom (HBV) allergy were followed during 1–2 years of immunotherapy. HBV‐specific IgG antibody levels increased in all patients but one. HBV‐specific IgE antibodies decreased slightly during the first year of therapy. The ratio HBV‐specific IgG‐/IgE showed a marked increase during the first year for most of the patients, and a further increase during the second year in the four patients followed that long. As could be expected an increased radiostaining was found after 1 year of treatment to all important allergens in IgG CRIE, but after 2 years a sustained or increased radiostaining was obtained to phospholipase (PLA) alone. A decreased radiostaining might more easily be seen with weaker immunogens.