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Reduction of histamine‐induced bronchoconstriction by magnesium in asthmatic subjects
Author(s) -
Rolla G.,
Bucca C.,
Bugiani M.,
Arossa W.,
Spinaci S.
Publication year - 1987
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1987.tb02198.x
Subject(s) - bronchoconstriction , histamine , spirometry , medicine , inhalation , asthma , magnesium , anesthesia , saline , endocrinology , chemistry , organic chemistry
The effects of inhaled MgSO 4 on histamine bronchoprovocation test (BPT) were studied in nine asthmatics in clinical remission (FEV 1 > 80% of predicted). Patients performed histamine BPT on 2 separate days, one day after saline and the other after MgSO 4 inhalation, in a randomized double‐blind design. Spirometry and flow/volume curve were recorded on each test day before and 5 min after NaCl or MgSO 4 . No significant difference was observed in lung function measurements 2 days before and after either NaCl or MgSO 4 . The dose of histamine which produced a 20% decrease in control FEV 1 (PD 20 FEV 1 ) was significantly increased by aerosolized MgSO 4 (from 0.177 ± 0.036 mg after NaCl to 0.350 ± 0.085 after MgSO 4 , P < 0.05. After MgSO 4 the dose‐steps of histamine concentration increased two‐fold in two subjects and one‐fold in five.