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Anaphylaxis after intra‐articular injection of orgotein
Author(s) -
DíezGómez M. L.,
Hinojosa M.,
Moneo I.,
Losada E.
Publication year - 1987
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1987.tb02190.x
Subject(s) - anaphylaxis , superoxide dismutase , immunoglobulin e , anaphylactic reaction , medicine , anaphylactic reactions , immunology , drug , allergy , pharmacology , dermatology , antibody , oxidative stress
Orgotein, a recently introduced anti‐inflammatory agent, is the generic name accepted in the U.S.A. for the drug version of copper‐zinc superoxide dismutase. This metallo‐enzyme is obtained from bovine liver and has a molecular weight of about 32,000. We report on a patient to whom an intra‐articular injection of orgotein caused an anaphylactic reaction. An IgE‐mediated mechanism was suggested by an immediate positive skin test to orgotein and by the finding of specific IgE against orgotein in the patient's serum.