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Nebulization treatment with saline compared to bromhexine in treating chronic sinusitis in asthmatic children
Author(s) -
Bever H. P. S.,
Bosmans J.,
Stevens W. J.
Publication year - 1987
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1987.tb02184.x
Subject(s) - medicine , saline , anesthesia , chronic sinusitis , sinusitis , asthma , nebulizer , gastroenterology , surgery
Twenty children aged 3 to 14 years with a history of bronchial asthma complicated by chronic sinusitis were studied in a double‐blind study. Patients received, at random, over a period of 2 weeks, either 2 ml saline or 2 ml bromhexine (2 mg/ml) t.i.d. by means of a home nebulizer. A significant decline of clinical symptoms during both nebulization treatments as compared to the pretreatment symptom score was observed (mean score of 1.5 ± 0.7 and 0.5 ± 0.8, respectively, ( P 0.01). Both types of nebulization were equally efficient in reducing the symptom score. Radiological abnormalities were significantly more reversed after saline nebulization as compared with bromhexine ( P < 0.05), although both treatments showed radiological improvement ( P < 0.01). The present study indicates that nebulization with saline may have some beneficial effect on chronic sinusitis in asthmatic children. Bromhexine was not superior to saline for this purpose.