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A preliminary evaluation of the effect of N‐acetyl‐aspartyl‐glutamate on pollen nasal challenge as measured by rhinomanometry and symptomatology
Author(s) -
Ghaem A.
Publication year - 1987
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1987.tb00394.x
Subject(s) - rhinomanometry , placebo , nasal administration , medicine , anesthesia , sensitization , allergy , mucous membrane of nose , immunology , surgery , nose , pathology , alternative medicine
The preventive effect of a nasally administered single dose of the dipeptide N‐acetyl‐aspartyl‐glutamate (NAAGA) on pollen‐induced early nasal reaction as measured by rhinomanometry and symptomatology was investigated in a double‐blind cross‐over placebo controlled study in 18 patients with nasal sensitization to grass pollen. Mean nasal airways resistance at 20, 40, and 60 min post challenge was, respectively, 33%, 37% (P = 0.03) and 27% less after NAAGA than after placebo administration in the same patients. In contrast, no significant effect on sneeze count and rhinorrhoea was found.