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Adrenocortical function in children on high‐dose steroid aerosol therapy
Author(s) -
Prahl P.,
Jensen T.,
BjerregaardAndersen H.
Publication year - 1987
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1987.tb00379.x
Subject(s) - body surface area , basal (medicine) , medicine , endocrinology , glucocorticoid , urinary system , excretion , corticosteroid , hydrocortisone , insulin
The adrenocortical function was investigated in 18 children treated with high‐doses of inhaled glucocorticoid aerosol (mean: 1965 μg/1.73 m 2 body surface a day). Basal serum cortisol was only below the normal range in patients treated with doses exceeding 2500 μg/1.73 m 2 body surface. 15 of 18 children had normal 24 h urinary free cortisol excretion, compared with 27 normal children matched for age, sex and body surface. Three patients taking more than 2400 μg/1.73 m 2 body surface showed excretion values below the range for the normal controls. 10 of 12 patients showed a normal response to a short ACTH stimulation test. One patient treated with 3300 μg/1.73 m 2 body surface showed no response and one patient gave a borderline response to ACTH. We concluded that doses up to 2000 μg/1.73 m 2 body surface/24 h can be administered by pressurized aerosol with little risk of adrenocortical suppression.