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Leucocyte migration inhibition in diphtheria toxoid hypersensitivity
Author(s) -
Saxby M. F.,
Salaman M. R.,
Sargent I. L.
Publication year - 1987
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1987.tb00366.x
Subject(s) - diphtheria toxin , diphtheria , delayed hypersensitivity , immunology , antigen , toxoid , medicine , transformation (genetics) , biology , toxin , microbiology and biotechnology , immunization , vaccination , genetics , gene
A donor who was highly reactive to diphtheria toxoid (DT) in delayed hypersensitivity and in lymphocyte transformation showed scant evidence of antigen‐induced inhibition in the direct leucocyte migration agarose test. Other donors, weak or negative to DT in skin test and transformation, did show evidence of inhibition. Although the migration test is useful in assessing cellular reactivity to tubercular antigen, these results question its suitability for DT.