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Timothy‐Specific IgG Antibody Levels Vary with the Pollen Seasons
Author(s) -
Nordvall S. L.,
Larson P. H.,
Johansson S. G. O.
Publication year - 1986
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1986.tb00349.x
Subject(s) - antibody , immunoglobulin e , immunology , antigen , specific antibody , biology , chemistry
Serum samples were collected from eight grass pollen hypersensitive children during a 4‐year period. The sera were assayed for contents of timothy‐specific IgE antibodies by RAST. Timothy‐specific IgG and IgA antibodies were quantified by a refined ELISA in which covalent binding of the antigen to the polystyrene solid phase had been performed. IgG antibodies were also assayed by a Sepharose‐protein‐A technique with radiolabelled timothy allergens as the antigen. It was possible to register clearcut seasonal variations with postseasonally boosted antibody levels not only of timothy‐specific IgE but also of IgG antibody. Both igG1 and IgG4 antibodies specific for timothy showed seasonal variations of a similar degree. It was not possible to register seasonal variations of the same magnitude of timothy‐specific IgA antibodies.